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Open Access Case Report

Transient neuromyopathy after bromide intoxication in a dog with idiopathic epilepsy

Sonja Steinmetz1*, Andrea Tipold1, Thomas Bilzer2 and Henning Christian Schenk1

Author Affiliations

1 Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover, 30559, Germany

2 Institute of Neuropathology, University of Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany

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Irish Veterinary Journal 2012, 65:19  doi:10.1186/2046-0481-65-19

Published: 5 December 2012

Abstract

A seven-year old Australian Shepherd, suffering from idiopathic epilepsy under treatment with phenobarbitone and potassium bromide, was presented with generalised lower motor neuron signs. Electrophysiology and muscle-nerve biopsies revealed a neuromyopathy.

The serum bromide concentration was increased more than two-fold above the upper reference value.

Clinical signs disappeared after applying diuretics and reducing the potassium bromide dose rate. This is the first case report describing electrophysiological and histopathological findings associated with bromide induced lower motor neuron dysfunction in a dog.

Keywords:
Epilepsy; Intoxication; Lower motor neuron signs; Myopathy; Potassium bromide